Acronym: RadioMag

Participating Scientific and Research Organizations (SROs) and their acronyms;

“VINČA” Institute of Nuclear Sciences – National Institute of the Republic of Serbia, University of Belgrade, Belgrade, Serbia (VINS);

Call for proposal: The Program PRISMA

About the Project

RadioMag Project’s aim is to introduce a unique combination of internal radiation therapy (nanobrachytherapy (NBT)) and heating, which relies on nanoconstructs labelled with therapeutic radionuclides. As generators of simultaneous (bi-modal) local nanobrachytherapy and local magnetic hyperthermia (MH), these nanoconstructs by new approaches are expected to boost cancer combat by synergism or a cumulative effect. RadioMag also addresses the design of new nanoconstructs based on multicore magnetic nanoparticles (MNPs) with flower-like morphology and single MNPs with different morphologies and high heating efficiency in MH therapy. The implementation plan concerns the synthesis of MNPs based on magnetite and maghemite and their coating with thin-layer organic compounds suitable for radiolabelling with therapeutic radionuclides (177Lu, 90Y, 131I). Samples analysis will be used to elucidate chemical, physical and biological underlying mechanisms at the nanoscale and to improve tailoring of the desired properties. The efficacy of the bi-modal therapy will be tested in vitro/in vivo on the CT-26 murine colon and 4T1 metastatic murine mammary carcinoma models. Besides scientific impact, the main anticipated Project outcome is the fabrication of radioactive nanoconstructs with improved therapeutic effect verified in preclinical testing, as the first step in the development of next-generation radiopharmaceuticals (magnetic nano radiopharmaceuticals) for application in bi-modal therapy.

Graphical abstract of the Project: 1. Design, synthesis and radiolabelling of nanoconstructs; 2. Analysis of physical, chemical and biological properties and mechanisms; 3. Preclinical studies of radioactive nanoconstructs (*in vitro/in vivo*).

Dissemination

2024. papers

Vranješ-Đurić, S., Milanović, Z., Mirković, M., Radović, M. and Perić, M., 2024.
On the driving forces behind the change of reduction potentials and the prediction of redox properties through analysis of EPR hyperfine couplings in VO (acac) 2pyr and VO (acac) 2 imidazole complexes. A DFT study. Polyhedron, p.117049. DOI: https://doi.org/10.1016/j.poly.2024.117049

Ognjanović, M., Bošković, M., Kolev, H., Dojčinović, B., Vranješ-Đurić, S. and Antić, B., 2024. Synthesis, Surface Modification and Magnetic Properties Analysis of Heat-Generating Cobalt-Substituted Magnetite Nanoparticles. Nanomaterials, 14(9), p.782. DOI: https://doi.org/10.3390/nano14090782

Ognjanović, M., Mirković, M., Radović. M., Vranješ-Đurić, S., Antić, B., Unveiling the impact of the chemical composition of ternary ferrites on specific loss power, 14th International Conference on the Scientific and Clinical Applications of Magnetic Carriers, Barcelona, Spain.